The DCRC is not currently leading trials of curative therapies for dementia

A priority for the DCRC is dementia prevention and understanding risk. Several programs of activity are exploring modifiable lifestyle factors, and are using large scale and longitudinal data.

 
Some major programs and activities 
 

Alzheimer's Disease
Risk Index (ANU-ADRI)

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Cognitive Stimulation Therapy and 'brain training'

 

“If older people increased efforts to address risk factors by just 5 or 10%, several million people could keep dementia at bay"

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DCRC projects inform public awareness campaigns about reducing risk for dementia


Here is a list of key DCRC projects that are currently active - to view a full list, including historical and completed projects, please use the search project at top left of this page)
 

PROJECT NAME
(listed alphabetically)

TEAM LEAD

CONTACT DCRC

A pilot community, case-control study examining environmental and lifestyle risk factors for younger onset dementia.

Dr Adrienne Withall
Prof Brian Draper

UNSW

A pilot study to estimate the prevalence of dementia in Torres Strait Islander Communities

Dr Edward Strivens
Prof Leon Flicker

UNSW

A randomised controlled trial of reducing prolonged sitting to improve cognitive function in insufficiently active frail older adults

Dr Paul Gardiner
Prof Nicola Lautenschlager
Prof Kaarin Anstey

ANU

A systematic review of the interaction between APOE and modifiable risk factors on the risk of dementia

A/Prof Lee-Fay Low
Prof Henry Brodaty

UNSW

A tale of three cities - comparison of the Memory and Ageing Sydney (MAS), and Australian Imaging Biomarker and Lifestyle (AIBL) studies

Prof Henry Brodaty
Prof Perminder Sachdev
Prof David Ames
Dr Simone Reppermund

UNSW

A trial of the Home Independence Program targeted for people living with dementia (HIP-D): Improving quality of life

Prof Gill Lewin
A/Prof Barbara Horner
Ms Sarah White
Prof Elizabeth Beattie

QUT

Acculturation and Depression in Older Migrants in Australia

Mr Tze Wei Chan
A/Prof Lee-Fay Low
Dr Jess Baker

UNSW

AIBL Imaging III: Imaging in AIBL at 6 year follow-up.

Prof Christopher Rowe
A/Prof Victor Villemagne
Prof David Ames
Prof Ralph Martins

ANU

An interactive multi-factorial model of dementia prevalence in the Australian population

Dr Victor Vickland
Prof Henry Brodaty

UNSW

ANDI-II-1C Taking research tools into clinical Practice: Image similarity metrics

Dr Nicolas Cherbuin
Dr Andrew Janke
Dr Moyra Mortby

ANU

ANDI-II-A Taking research tools into clinical Practice: Model-based image "type" detection

Dr Andrew Janke
Dr Nicolas Cherbuin
Dr Moyra Mortby

ANU

ANDI-II-B Taking research tools into clinical Practice: Symmetric model generation

Dr Andrew Janke
Dr Nicolas Cherbuin
Dr Moyra Mortby

ANU

Assess suitability of multiplexing

Prof Ralph Martins
Dr Andrea C. Wilson

ANU

Assessing Alzheimer’s disease risk online: What is the relationship between risk factors and objective and subjective memory performance?

Dr Maree Farrow
Prof Kaarin Anstey
A/Prof Kathryn Ellis

ANU

Australian neuropsychological normative study of older persons

Dr Nicole Kochan
Prof Perminder Sachdev
Prof Henry Brodaty
Prof Kaarin Anstey
Dr Melissa Slavin

UNSW

BBL - GP Feasibility and intervention: Adapting and evaluating an evidence-based dementia risk reduction program for use in primary care

Prof Kaarin Anstey
Dr Nicolas Cherbuin
Dr Alex Bahar-Fuchs
Dr Maree Farrow
Dr Kerry Sargent-Cox

ANU

Brain Training Laboratory

Dr Amit Lampit
Prof Perminder Sachdev
Prof Henry Brodaty
A/Prof Michael Valenzuela

UNSW

Cancer treatment and cancer as risk factors for neurocognitive impairment

Prof Kaarin Anstey
Dr Nicolas Cherbuin
Prof Perminder Sachdev

ANU

Cerebrospinal Fluid (CSF) Biomarkers for use in Alzheimer's Disease research

Dr Andrea C. Wilson
A/Prof Kathryn Ellis
Prof Ralph Martins

ANU

Characterisation of lipid profiles using state-of-the-art electrospray ionization mass spectrometry (ESI-MS) to determine profiles of individuals with Alzheimer's disease and to determine the effect of these on Neuroimaging and how they are affected by Physical Activity, with the aim of identifying novel biomarkers.

Ms Samantha Gardener

ANU

Cognition following non-cardiac surgery and anaesthesia: a study of neuropsychological and functional changes in the first year post-procedure (PhD Project)

Premilla Chinnappa-Quinn

UNSW

Cognitive decline in community dwelling older people

Prof Henry Brodaty
Dr Megan Heffernan

UNSW

Cognitive decline trajectories in community dwelling older adults

Prof Henry Brodaty
Dr Megan Heffernan

UNSW

Cognitive outcome after stroke

Dr Catherine Dong
Prof Perminder Sachdev

UNSW

Cognitive outcomes in the ageing cannabis user

Dr Adrienne Withall
Prof Brian Draper

UNSW

Cognitive training in older persons with mild cognitive impairment, with and without mood disorders

Dr Alex Bahar-Fuchs
Prof Kaarin Anstey
Dr Nicolas Cherbuin
Prof George Rebok
Prof Linda Clare

ANU

Computerised neuropsychological testing for early diagnosis of mild cognitive impairment and dementia

Dr Nicole Kochan
Prof Perminder Sachdev
Dr Melissa Slavin
Prof Henry Brodaty

UNSW

Dementia and Successful Cognitive Ageing in Centenarians: An International Consortium

Dr Melissa Slavin
Prof Henry Brodaty
Prof Perminder Sachdev

UNSW

Dementia Outcomes Measurement Suite (DOMS)

Prof Henry Brodaty
Dr Liesbeth Aerts
Mr Adam Bentvelzen

UNSW

Dementia Prevention Project 1: Evidence on dementia risk reduction, risk assessment and intervention

Prof Kaarin Anstey
Prof Marc Budge
Prof George Rebok

ANU

Dementia Prevention Project 2: Development of a dementia prevention intervention

Prof Kaarin Anstey
Dr Nicolas Cherbuin
Dr Pushpani Menaka Herath
Prof Marc Budge
Prof George Rebok

ANU

Dementia Prevention Project 3: Body, Brain, Life RCT for risk reduction

Prof Kaarin Anstey
Dr Nicolas Cherbuin
Dr Alex Bahar-Fuchs
Ms Jocelyn Barnett
Dr Pushpani Menaka Herath

ANU

Determining the prevalence of brain amyloid plaques in older members of the Australian community.

Prof Christopher Rowe
Prof Colin Masters

ANU

Developing a cohort projections model to estimate the population level impact of alternative risk factor profiles on dementia prevalence in Australia over the next 50 years.

Prof Laurie Brown

Prof Kaarin Anstey

ANU

Development and validation of short forms of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI)

Ms Sarang Kim
Prof Kaarin Anstey
Dr Nicolas Cherbuin

ANU

Development of a website for providing authoritative evidence and practical advice on dementia risk reduction

Dr Maree Farrow
Mr Jack Sach
Prof Kaarin Anstey
A/Prof Michael Woodward

ANU

Environmental and lifestyle risk factors for younger onset dementia.

Ms Monica Cations

UNSW

Environmental toxins and dementia risk - a review

Dr Maree Farrow
Prof Kaarin Anstey
Dr Nicolas Cherbuin

ANU

Evaluating the Australian National University Alzheimer’s disease risk index (ANU-ADRI) – does it correlate with memory performance?

Dr Maree Farrow

ANU

Evaluating the impact of the environment on physical activity levels and healthcare outcomes for people with dementia living in residential aged care facilities

A/Prof Victoria Traynor
Prof Lynn Chenoweth
Professor Yun-Hee Jeon

UNSW

Evaluation of candidate biomarkers in platelets

Prof Ralph Martins
Dr Andrea C. Wilson
Dr Stephanie Rainey-Smith

ANU

Evaluation of Mind your Mind community presentations: do they promote behavioural change?

Dr Maree Farrow
Mr Jack Sach
Prof Kaarin Anstey
Ms Suha Ali

ANU

Evaluation of online information on dementia risk reduction: does it promote behavioural change in individuals and in clinical practice?

Dr Maree Farrow
Mr Jack Sach
Ms Suha Ali

ANU

Exercising the brain - guidelines

Ben Rattray
Dr Kate Pumpa
Dr Allison Bielak
Ms Disa Smee
Dr Nicolas Cherbuin
Prof Kaarin Anstey

ANU

Framework development for National Dementia Prevention Promotion and Early Intervention

Dr David Lie
Dr Melinda Martin-Khan
Dr Catherine Travers

ANU

Genetic and environmental contributions to amyloid burden in older Australians: a PiB-PET imaging study of twins

Dr Melissa Slavin
Prof Christopher Rowe
Professor Julian Trollor
Prof Perminder Sachdev
Prof Henry Brodaty

UNSW

Genetic factors in dementia in elderly Australians

Ms Arezoo Assareh
Prof Perminder Sachdev

UNSW

Genetics of the integrity of the white matter in older adults (post-graduate student project)

Sri Chandana Kanchibhotla
Dr Karen Mather
Prof Perminder Sachdev

UNSW

Identifying specific biomarkers for AD

Prof Ralph Martins
Dr Veer Bala Gupta

ANU

Improvement of GP use of screening for cognitive impairment

Prof Henry Brodaty
Prof Dimity Pond
Prof Brian Draper
Dr Katrin Seeher
Dr Liesbeth Aerts

UNSW

iPhone and iPad dementia risk reduction app evaluation

Dr Maree Farrow
Dr Chris Hatherly

ANU

Is anxiety a risk factor in cognitive ageing?

Mr Richard Arthur

ANU

Knowledge Translation Pathway for Early/Timely Diagnosis of Dementia

Dr Melinda Martin-Khan

ANU

Longitudinal social and biomedical risk factors for incident dementia and cognitive decline in urban and regional Aboriginal Australians

Dr Kylie Radford
Prof Tony Broe
Prof Brian Draper
Dr Gail Garvey

 

Managing Substance Abuse in the Over 60s

Prof Brian Draper

UNSW

Manuals for Younger Onset Dementia

Dr Adrienne Withall

UNSW

Measuring tau rate of change and propagation: implications for diagnosis, prognosis and therapy trials in AD.

Prof Christopher Rowe
A/Prof Victor Villemagne
Prof Colin Masters

ANU

Neuropsychology and the AIBL study: Progressing the clinical neuropsychological phenotype of Alzheimer's disease.

Prof Colin Masters
Prof Paul Maruff
A/Prof Kathryn Ellis
Prof David Ames

ANU

Online dementia risk reduction interventions

Dr Maree Farrow
Mr Jack Sach
Ms Suha Ali
Prof Kaarin Anstey
A/Prof Michael Woodward

ANU

Personality factors INDIGO Trial

A/Prof Kathryn Ellis
Prof Nicola Lautenschlager
A/Prof Kay Cox
Dr Anita Goh

ANU

Physical Activity guidelines for older adults with subjective cognitive decline or mild cognitive impairment

Prof Nicola Lautenschlager
Prof Kaarin Anstey
Prof Keith Hill
Prof Dimity Pond
A/Prof Kay Cox
A/Prof Kathryn Ellis
B. Dow

ANU

Plasma AB isoforms measurement

Prof Colin Masters
Prof Ralph Martins
A/Prof Kathryn Ellis

ANU

Plasma apoE measurement

Prof Ralph Martins
Dr Andrea C. Wilson
Prof Colin Masters

ANU

Plasma IDE measurement

Prof Ralph Martins
Dr Andrea C. Wilson
Prof Colin Masters

ANU

Pre-symptomatic diagnosis of neurodegenerative diseases with Positron Emission Tomography (PET) exploring vascular risk and the lag phase

Dr Paul Yates
Prof Christopher Rowe
Prof Colin Masters

ANU

Predicting cognitive trajectory in ageing

Ms Ada Lo
Prof Perminder Sachdev

UNSW

Predictors and correlates of cognitive decline in people with intellectual disability

Professor Julian Trollor
Prof Henry Brodaty
Prof Perminder Sachdev

UNSW

Predictors of complicated grief and health outcomes in family caregivers of people with dementia - Joint AAR/DCRC Postgraduate Research Scholarship

Dr Patricia Shuter
Prof Elizabeth Beattie

QUT

Prevalence & correlates of neuropsychiatric symptoms among premutation carriers of the FMR1 gene - PhD project

Dr Rachael Birch
Professor Julian Trollor

UNSW

Prevalence of Dementia in the Torres Strait

Dr Edward Strivens
Prof Leon Flicker

UNSW

Profile, Correlates and Predictors of Cognitive Decline in Fragile X Premutation Carriers

Professor Julian Trollor

UNSW

Promoting Healthy Ageing in two at-risk populations: People with Intellectual Disability, and their family carers

Professor Julian Trollor
Elizabeth Evans
Prof Henry Brodaty
Prof Perminder Sachdev

UNSW

Prospective memory in dementia

Dr Claire Thompson
Dr Adrienne Withall
Prof Henry Brodaty

UNSW

Protecting brain health via Dementia risk reduction activities: Knowledge transfer for diverse communities

Prof Nicola Lautenschlager
A/Prof Kathryn Ellis
Dr Anita Goh
Prof Kaarin Anstey
Ms Sarang Kim
Dr Nicolas Cherbuin
Dr Moyra Mortby

ANU

Proteomics for discovery of novel biomarkers

Prof Ralph Martins
Dr Andrea C. Wilson
Prof Colin Masters

ANU

Proteomics for discovery of novel biomarkers

Prof Colin Masters
Prof Ralph Martins
A/Prof Kathryn Ellis

ANU

Responding to sexuality in residential aged care: The development of an assessment tool for people with dementia

Dr. Michael Bauer
Prof Rhonda Nay
Prof Elizabeth Beattie
Dr Deirdre Fetherstonhaugh

QUT

Sitting time Intervention

Prof Nicola Lautenschlager
Prof David Dunstan
A/Prof Kay Cox
Prof Kaarin Anstey
A/Prof Kathryn Ellis
Dr Elizabeth Cyarto
Dr Paul Gardiner

ANU

Successful ageing and cognitive decline in a community sample

Prof Henry Brodaty
Dr Megan Heffernan

UNSW

The Change in Cognition with Age Questionnaire (CICAQ)

Prof Henry Brodaty
Dr Megan Heffernan
A/Prof Lee-Fay Low

UNSW

The INSPIRED Study - Improving Service Provision in Early Onset Dementia

Prof Brian Draper
Dr Adrienne Withall
Professor Julian Trollor
Ms Monica Cations
Ms Fiona White

UNSW

The perceived and actual risk of Alzheimer's disease across the full adult lifespan

Dr Joanna Brooks
Prof Kaarin Anstey

ANU

The Public Health Benefits/Risks of Timely Diagnosis - Exploratory Studies

Dr Melinda Martin-Khan
Prof. Nancy A. Pachana
Dr Geoffrey Mitchell
Dr Maree Farrow
Dr David Lie
Dr Rupert McShane

ANU

The relationship of diet to neurocognitive health

Ms Sophie Chen

UNSW

The Sage-ID Study: The Predictors and Correlates of Cognitive Decline in People with Intellectual Disability: a Questionnaire study

Professor Julian Trollor
Prof Henry Brodaty
Prof Perminder Sachdev

UNSW

The Sydney Centenarian Study (DCRC sub-project)

Ms Zixuan Yang
Prof Perminder Sachdev

UNSW

The Sydney Stroke Study

Dr Adrienne Withall
Prof Henry Brodaty
Prof Perminder Sachdev

UNSW

Timely Diagnosis of Dementia

Dr Allan Shell
Prof Henry Brodaty

UNSW

Too Much of a Good Thing? Deprescribing Medications in Adults Aged Over 65 Years

Ms Amy Page
Dr Kathleen Potter
Prof Chris Etherton-Beer

UNSW

Transcranial direct current stimulation (tDCS) to enhance outcomes from computer facilitated cognitive training in patients with mild cognitive impairment (MCI)

Dr Adith Mohan
Prof Perminder Sachdev
Prof Henry Brodaty

UNSW

Understanding dementia in urban, rural and remote Aboriginal and Torres Strait Islander communities in Queensland

Dr Gail Garvey
Prof Elizabeth Beattie

QUT

Understanding how the neighbourhood environment influences brain and cognitive health in older adults

A/Prof Kathryn Ellis
Prof Nicola Lautenschlager

ANU

User experiences and perceptions of an online Alzheimer's disease risk assessment tool – the Australian National University Alzheimer’s disease risk index (ANU-ADRI)

Dr Maree Farrow
Prof Kaarin Anstey
Dr Nicolas Cherbuin
Dr Elodie O'Connor

ANU

Who benefits from dementia interventions? A study of motivations and barriers to lifestyle and behaviour changes for dementia prevention.

Ms Sarang Kim

ANU