Project Page

Back to search results

Genetic factors in dementia in elderly Australians

Ms Arezoo Assareh, Prof Perminder Sachdev
Research Centre DCRC Assessment and Better Care
Partner Institution Centre-based
Project Description

In this PhD research project, the interaction of imaging assessment and genetics of risk factors related to dementia will be investigated. The dementia-related endophenotypes that will be examined include cognitive function, decline in cognition, brain volumes, hippocampal volumes, and volumes of white matter hyperintensities (WMHs).

This investigation will be performed in a large well-characterised community cohort of older Australians. Candidate and novel genes identified by genome wide association studies and significantly associated with dementia-related endophenotypes will be investigated further using functional assays. The clarification of how environmental and genetic factors interact to increase or decrease susceptibility to dementia will contribute to our understanding of the risk factors and causes of dementia.

This research has implications in determining the causes of dementia and may eventually lead to new treatments.

Project Portfolio

Back to search results