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Transcranial direct current stimulation (tDCS) to enhance outcomes from computer facilitated cognitive training in patients with mild cognitive impairment (MCI)

Dr Adith Mohan, Prof Perminder Sachdev, Prof Henry Brodaty
Research Centre DCRC Assessment and Better Care
Partner Institution Centre-based / Centre for Healthy Brain Ageing (CHeBA) UNSW
Project Description

Pharmacological treatment of individuals with mild cognitive impairment (MCI) has not shown convincing effects either in delaying disease progression or in attenuating conversion rates to dementia (Raschetti 2007). Non pharmacological interventions are best considered an important part of the therapeutic approach to the MCI patient population.

Preliminary evidence suggests that cognitive remediation treatment (CRT), of which computer facilitated cognitive training (CFCT) being one approach, may be effective in improving cognition in patients with MCI.

A major limitation to current interventions, however, includes the generally large and intensive number of sessions required to show clinical benefit. As such, there is a need for novel strategies to further improve CRT methods.

This study proposes to investigate the use of CFCT combined with transcranial direct current stimulation (tDCS). Specifically, this study aims to directly investigate whether CFCT when combined with tDCS will be of greater clinical benefit than CFCT alone in patients with MCI in a randomised controlled trial.

Assessments conducted at baseline, post CFCT, and at 3 months follow-up will examine whether CFCT combined with tDCS produces greater cognitive and functional gains than CFCT alone and whether these gains are maintained over time.

** This project is currently recruiting **

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