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Research Centre DCRC Assessment and Better Care
Partner Institution Regenerative Neuroscience Group Brain & Mind Research Institute, Montefiore Randwick Campus
Project Description

Deterioration in global cognition (GC) is commonly thought to be an inevitable consequence of advanced age and defines transition from successful aging to cognitive impairment and dementia. Intense interest has focused on the potential for computerized cognitive training (CCT) to counter age-related GC decline, but efficacy has yet to be demonstrated in a randomized, double-blind, active-controlled trial.

We used a dose-response design to find significant GC effects after just 9 training sessions that subsequently peaked after 36 sessions. These gains decayed rapidly following training cessation, but some residual gains were conserved one year later.

In contradistinction to previous trials, we implemented multidomain CCT in a supervised group setting, an approach that is pragmatic, safe, efficacious and cost-effective. Next generation CCT technology and clinical practice should take underlying dose-response relationships into account when targeting GC in older adults.

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